GDC-0349
GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.
| Trivial name | RG-7603 |
| Catalog Number | S8040 |
| Molecular Formula | C24H32N6O3 |
| CAS# | 1207360-89-1 |
| Inchi | InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1 |
| Inchi Key | RGJOJUGRHPQXGF-INIZCTEOSA-N |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOCC5C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gdc-0349.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GDC-0349-chemical-structure-s8040.gif |