Midostaurin
Midostaurin is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM.
| Trivial name | PKC412, CGP 41251 |
| Catalog Number | S8064 |
| Molecular Formula | C35H30N4O4 |
| CAS# | 120685-11-2 |
| Inchi | InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H ,36,40)/t25-,26-,32-,35+/m1/s1 |
| Inchi Key | BMGQWWVMWDBQGC-IIFHNQTCSA-N |
| SMILES | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/midostaurin-pkc412.html |
| Additional Information | https://file.selleck.cn/downloads/struct/midostaurin(pkc412)-chemical-structure-s8064.gif |