Brigatinib
Brigatinib is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
| Trivial name | AP26113 |
| Catalog Number | S8229 |
| Molecular Formula | C29H39ClN7O2P |
| CAS# | 1197953-54-0 |
| Inchi | InChI=1S/C29H39ClN7O2P/c1-35-15-17-37(18-16-35)21-11-13-36(14-12-21)22-9-10-24(26(19-22)39-2)33-29-31-20-23(30)28(34-29)32-25-7-5-6-8-27(25)40(3,4)38/h5-10,19-21H,11-18H2,1-4H3,(H2,31,32,33,34) |
| Inchi Key | AILRADAXUVEEIR-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/brigatinib-ap26113.html |
| Additional Information | https://file.selleck.cn/downloads/struct/brigatinib-ap26113-chemical-structure-S8229.gif |