Gedatolisib (PKI-587)
Gedatolisib (PF-05212384, PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with IC50 of 0.4 nM, 5.4 nM and 1.6 nM in cell-free assays, respectively. Phase 2.
Trivial name | PF-05212384 |
Catalog Number | S2628 |
Molecular Formula | C32H41N9O4 |
CAS# | 1197160-78-3 |
Inchi | InChI=1S/C32H41N9O4/c1-38(2)27-11-13-39(14-12-27)29(42)24-5-9-26(10-6-24)34-32(43)33-25-7-3-23(4-8-25)28-35-30(40-15-19-44-20-16-40)37-31(36-28)41-17-21-45-22-18-41/h3-10,27H,11-22H2,1-2H3,(H2,33,34,4 3) |
Inchi Key | DWZAEMINVBZMHQ-UHFFFAOYSA-N |
SMILES | CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6 |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/pki587.html |
Additional Information | https://file.selleck.cn/downloads/struct/PKI-587-chemical-structure-s2628.gif |