Dabrafenib
Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
| Trivial name | GSK2118436, GSK2118436A |
| Catalog Number | S2807 |
| Molecular Formula | C23H20F3N5O2S2 |
| CAS# | 1195765-45-7 |
| Inchi | InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) |
| Inchi Key | BFSMGDJOXZAERB-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/dabrafenib-gsk2118436.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK2118436-chemical-structure-s2807.gif |