Dabrafenib
Dabrafenib is a mutant BRAFV600E specific inhibitor with IC50 of 0.7 nM in cell-free assays, with 7- and 9-fold less potency against B-Raf(wt) and c-Raf, respectively.
| Trivial name | GSK2118436, GSK2118436A |
| Catalog Number | S2807 |
| Molecular Formula | C25H23Cl2FN6O |
| CAS# | 1195765-45-7 |
| Inchi | InChI=1S/C25H23Cl2FN6O/c1-2-34-23-15(11-19(24(34)35)18-5-3-16(26)12-20(18)27)14-30-25(32-23)31-17-4-6-22(21(28)13-17)33-9-7-29-8-10-33/h3-6,11-14,29H,2,7-10H2,1H3,(H,30,31,32) |
| Inchi Key | DHKFOIHIUYFSOF-UHFFFAOYSA-N |
| SMILES | CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)Cl)Cl)NC4=CC(=C(C=C4)N5CCNCC5)F |
| Size | 20mg |
| Supplier Page | http://www.selleckchem.com/products/dabrafenib-gsk2118436.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GSK2118436-chemical-structure-s2807.gif |