LY2811376
LY2811376 is the first orally available non-peptidic β-secretase(BACE1) inhibitor with IC50 of 239 nM-249 nM, that act to decrease Aβ secretion with EC50 of 300 nM, demonstrated to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin. Phase 1.
| Trivial name | N/A |
| Catalog Number | S1528 |
| Molecular Formula | C15H14F2N4S |
| CAS# | 1194044-20-6 |
| Inchi | InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1 |
| Inchi Key | MJQMRGWYPNIERM-HNNXBMFYSA-N |
| SMILES | CC1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/LY2811376.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY2811376-chemical-structure-S1528.gif |