Agerafenib (CEP-32496)

Agerafenib (CEP-32496) is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret (c-Ret), PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. Phase 1/2.

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Trivial name	RXDX-105
Catalog Number	S8015
Molecular Formula	C24H22F3N5O5
CAS#	1188910-76-0
Inchi	InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)
Inchi Key	DKNUPRMJNUQNHR-UHFFFAOYSA-N
SMILES	CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
Size	5mg
Supplier Page	http://www.selleckchem.com/products/cep-32496.html
Additional Information	https://file.selleck.cn/downloads/struct/CEP-32496-chemical-structure-s8015.jpg