(+)-Nebivolol
This active molecular is a β-adrenergic receptor antagonist. Dexnebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and left ventricular failure in Europe. It is highly cardioselective under certain circumstances. In Apr 2015, US FDA approved an ANDA for nebivolol submitted by Amerigen. In Jan 2016, Forest Laboratories and the University of Chicago withdrew a phase II/III trial for Hypertension in patients with chronic obstructive pulmonary disease in USA .
| Catalog Number | 118457-15-1 |
| Alternative Name(s) | R67138; R-67138; R 67138; Dexnebivolol. (αR,α'R,2R,2'S)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; [2R-[2R*[R*[R*(S*)]]]]-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4- dihydro-2H-1-benzopyran-2-methanol; (S,R,R,R)-Nebivolol; Dexnebivolol; R 67138; d-Nebivolol; ' |
| Molecular Formula | C22H25F2NO4 |
| CAS# | 118457-15-1 |
| Purity | 98% |
| Inchi | InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22+/m1/s1 |
| Inchi Key | KOHIRBRYDXPAMZ-YHBROIRLSA-N |
| Size | Please inquire |
| Supplier Page | https://www.bocsci.com/nebivolol-cas-118457-15-1-item-256091.html |