MK-8353 (SCH900353)

MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay).

Price Not Available 10mM/1mL MK-8353 (SCH900353) Supplier Page

Trivial name	N/A
Catalog Number	S8701
Molecular Formula	C37H41N9O3S
CAS#	1184173-73-6
Inchi	InChI=1S/C37H41N9O3S/c1-24(2)49-32-12-9-28(20-38-32)34-30-19-29(10-11-31(30)41-42-34)40-36(48)37(50-4)15-18-45(22-37)21-33(47)46-16-13-26(14-17-46)25-5-7-27(8-6-25)35-39-23-44(3)43-35/h5-13,19-20,23-2 4H,14-18,21-22H2,1-4H3,(H,40,48)(H,41,42)/t37-/m0/s1
Inchi Key	KPQQGHGDBBJGFA-QNGWXLTQSA-N
SMILES	CC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)C4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/mk-8353-sch900353.html
Additional Information	https://file.selleck.cn/downloads/struct/mk-8353-sch900353-chemical-structure-s8701.gif