Vadimezan (DMXAA)

Vadimezan (DMXAA) is a vascular disrupting agents (VDA) and competitive inhibitor of DT-diaphorase with Ki of 20 μM and IC50 of 62.5 μM in cell-free assays, respectively. DMXAA (Vadimezan) is also a STING agonist with potential antineoplastic activity. DMXAA (Vadimezan) potently induces IFN-β but relatively low TNF-α expression in vitro. DMXAA (Vadimezan) has antiviral activity. Phase 3.

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Trivial name	ASA404, NSC 640488
Catalog Number	S1537
Molecular Formula	C17H14O4
CAS#	117570-53-3
Inchi	InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
Inchi Key	XGOYIMQSIKSOBS-UHFFFAOYSA-N
SMILES	CC1=C(C2=C(C=C1)C(=O)C3=CC=CC(=C3O2)CC(=O)O)C
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/DMXAA(ASA404).html
Additional Information	https://file.selleck.cn/downloads/struct/DMXAA-ASA404-chemical-structure-S1537.gif