PKI-402
PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM, respectively; also potent to PI3Kα mutants E545K and H1047R.
| Trivial name | N/A |
| Catalog Number | S2739 |
| Molecular Formula | C25H23Cl2N7O4 |
| CAS# | 1173204-81-3 |
| Inchi | InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32) /t18-,20-,21-,24-/m1/s1 |
| Inchi Key | ZXGGCBQORXDVTE-UMCMBGNQSA-N |
| SMILES | C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pki-402.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PKI-402-chemical-structure-s2739.gif |