VU0238429
VU0238429 (M5 PAM) is the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5/M5) with EC50 of 1.16 μM at M5 and both > 30 μM at M1 and M3. VU0238429 shows no potentiator activity at M2 or M4.
Trivial name | M5 PAM |
Catalog Number | S2646 |
Molecular Formula | C17H12F3NO4 |
CAS# | 1160247-92-6 |
Inchi | InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3 |
Inchi Key | CKLGZXFOLMHCMC-UHFFFAOYSA-N |
SMILES | COC1=CC=C(C=C1)CN2C3=C(C=C(C=C3)OC(F)(F)F)C(=O)C2=O |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/vu0238429.html |
Additional Information | https://file.selleck.cn/downloads/struct/vu0238429-chemical-structure-s2646.gif |