VU0238429
VU0238429 (M5 PAM) is the first positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5/M5) with EC50 of 1.16 μM at M5 and both > 30 μM at M1 and M3. VU0238429 shows no potentiator activity at M2 or M4.
| Trivial name | M5 PAM |
| Catalog Number | S2646 |
| Molecular Formula | C17H13Cl2NO4 |
| CAS# | 1160247-92-6 |
| Inchi | InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22) |
| Inchi Key | HLXSCTYHLQHQDJ-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/vu0238429.html |
| Additional Information | https://file.selleck.cn/downloads/struct/vu0238429-chemical-structure-s2646.gif |