TCS7010 (Aurora A Inhibitor I)
TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.
| Trivial name | TC-S 7010 |
| Catalog Number | S1451 |
| Molecular Formula | C17H11BrFN3O2 |
| CAS# | 1158838-45-9 |
| Inchi | InChI=1S/C17H11BrFN3O2/c18-12-4-1-5-13(19)15(12)16(23)10-7-14(21-8-10)17(24)22-11-3-2-6-20-9-11/h1-9,21H,(H,22,24) |
| Inchi Key | ATKCERYALDNMPL-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)Br)C(=O)C2=CNC(=C2)C(=O)NC3=CN=CC=C3)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/Aurora-A-Inhibitor-I.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Aurora-A-Inhibitor-I-chemical-structure-S1451.gif |