TCS7010 (Aurora A Inhibitor I)
TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway.
| Trivial name | TC-S 7010 |
| Catalog Number | S1451 |
| Molecular Formula | C26H29ClN2O4S |
| CAS# | 1158838-45-9 |
| Inchi | InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+ |
| Inchi Key | LLLQTDSSHZREGW-AATRIKPKSA-N |
| SMILES | CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Aurora-A-Inhibitor-I.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Aurora-A-Inhibitor-I-chemical-structure-S1451.gif |