Avagacestat (BMS-708163)
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Trivial name | N/A |
Catalog Number | S1262 |
Molecular Formula | C21H15F2N3O3S |
CAS# | 1146699-66-2 |
Inchi | InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) |
Inchi Key | XRDVXQQZLHVEQZ-UHFFFAOYSA-N |
SMILES | C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/BMS-708163.html |
Additional Information | https://file.selleck.cn/downloads/struct/BMS-708163-chemical-structure-S1262.gif |