Avagacestat (BMS-708163)

Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Price Not Available 50mg Avagacestat (BMS-708163) Supplier Page

Trivial name	N/A
Catalog Number	S1262
Molecular Formula	C20H17ClF4N4O4S
CAS#	1146699-66-2
Inchi	InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1
Inchi Key	XEAOPVUAMONVLA-QGZVFWFLSA-N
SMILES	C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl
Size	50mg
Supplier Page	http://www.selleckchem.com/products/BMS-708163.html
Additional Information	https://file.selleck.cn/downloads/struct/BMS-708163-chemical-structure-S1262.gif