PF-8380
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.
| Catalog Number | T3631 |
| Research Area | Metabolism |
| Molecular Formula | C22H21Cl2N3O5 |
| CAS# | 1144035-53-9 |
| Purity | 99.45% |
| SMILES | C1CN(CCN1CCC(=O)c1cc2c(cc1)[nH]c(=O)o2)C(=O)OCc1cc(cc(c1)Cl)Cl |
| Size | 25 mg |
| Supplier Page | https://www.targetmol.com/compound/PF-8380 |
| Additional Information | https://www.targetmol.com/datasheet/T3631 |