Capivasertib (AZD5363)
Capivasertib (AZD5363) potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.
Trivial name | N/A |
Catalog Number | S8019 |
Molecular Formula | C21H25ClN6O2 |
CAS# | 1143532-39-1 |
Inchi | InChI=1S/C21H25ClN6O2/c22-15-3-1-14(2-4-15)17(6-12-29)27-20(30)21(23)7-10-28(11-8-21)19-16-5-9-24-18(16)25-13-26-19/h1-5,9,13,17,29H,6-8,10-12,23H2,(H,27,30)(H,24,25,26)/t17-/m0/s1 |
Inchi Key | JDUBGYFRJFOXQC-KRWDZBQOSA-N |
SMILES | C1CN(CCC1(C(=O)NC(CCO)C2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4 |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/azd5363.html |
Additional Information | https://file.selleck.cn/downloads/struct/AZD5363-chemical-structure-s8019.gif |