Stenoparib (E7449)
Stenoparib (E7449, 2X-121, MGI25036) is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 and also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
| Trivial name | 2X-121, MGI25036 |
| Catalog Number | S8419 |
| Molecular Formula | C18H15N5O |
| CAS# | 1140964-99-3 |
| Inchi | InChI=1S/C18H15N5O/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23/h1-7H,8-10H2,(H,22,24)(H,19,20,21) |
| Inchi Key | JLFSBHQQXIAQEC-UHFFFAOYSA-N |
| SMILES | C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3 |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/e7449.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7449-chemical-structure-S8419.gif |