Cabozantinib malate

Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis.

Price Not Available 10mM/1mL Cabozantinib malate Supplier Page

Trivial name	XL184
Catalog Number	S4001
Molecular Formula	C28H24FN3O5.C4H6O5
CAS#	1140909-48-3
Inchi	InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33) (H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1
Inchi Key	HFCFMRYTXDINDK-WNQIDUERSA-N
SMILES	COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/cabozantinib-malate.html
Additional Information	https://file.selleck.cn/downloads/struct/Cabozantinib-malate-chemical-structure-s4001.gif