Q-VD-OPH
Q-VD-OPH is a broad-spectrum caspase inhibitor that blocks caspases-3, -7, -8, -9, -10, and -12. It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK and Boc-D-FMK.
| Catalog Number | R0812 |
| Alternative Name(s) | pan-Caspase inhibitor (fluoromethylketone), N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone |
| Research Area | Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). |
| Molecular Formula | C26H25F2N3O6 |
| CAS# | 1135695-98-5 |
| Purity | >98% |
| Inchi | InChI=1S/C26H25F2N3O6/c1-14(2)23(31-25(35)19-11-10-15-6-3-4-9-18(15)29-19)26(36)30-20(12-22(33)34)21(32)13-37-24-16(27)7-5-8-17(24)28/h3-11,14,20,23H,12-13H2,1-2H3,(H,30,36)(H,31,35)(H,33,34)/t20-,23-/m0/s1 |
| Inchi Key | OOBJCYKITXPCNS-REWPJTCUSA-N |
| SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2 |
| Size | Inquiry |
| Supplier Page | https://www.creative-peptides.com/product/q-vd-oph-item-r0812-34614.html |