VER155008
VER155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78 (HSPA5, Bip), respectively, >100-fold selectivity over HSP90. VER155008 inhibits autophagy and causes reduced levels of HSP90 client proteins.
| Catalog Number | S7751 |
| Molecular Formula | C25H23Cl2N7O4 |
| CAS# | 1134156-31-2 |
| Inchi | InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32) /t18-,20-,21-,24-/m1/s1 |
| Inchi Key | ZXGGCBQORXDVTE-UMCMBGNQSA-N |
| SMILES | C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=NC=NC(=C4N=C3NCC5=CC(=C(C=C5)Cl)Cl)N)O)O)C#N |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/ver155008.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ver155008-chemical-structure-s7751.gif |