Letrozole
Letrozole is a third generation inhibitor of aromatase with IC50 of 0.07-20 nM in cell-free assays.It has no effect on the plasma levels of 17α-OH progesterone, thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), or androstenedione and does not affect normal urine electrolyte excretion or thyroid function in clinical studies. Letrozole induces autophagy.
| Trivial name | CGS 20267 |
| Catalog Number | S1235 |
| Molecular Formula | C17H11N5 |
| CAS# | 112809-51-5 |
| Inchi | InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H |
| Inchi Key | HPJKCIUCZWXJDR-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/Letrozole.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Letrozole-chemical-structure-S1235.gif |