IWR-1-endo
IWR-1-endo (endo-IWR 1, IWR-1) is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
| Trivial name | endo-IWR 1, IWR-1 |
| Catalog Number | S7086 |
| Molecular Formula | C25H19N3O3 |
| CAS# | 1127442-82-3 |
| Inchi | InChI=1S/C26H21N3O3/c1-26-18-10-7-17(14-18)21(26)24(31)29(25(26)32)19-11-8-16(9-12-19)23(30)28-20-6-2-4-15-5-3-13-27-22(15)20/h2-13,17-18,21H,14H2,1H3,(H,28,30)/t17-,18+,21+,26+/m1/s1 |
| Inchi Key | JLUGUZSHOFCGPZ-SJGOCFNWSA-N |
| SMILES | C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/iwr-1-endo.html |
| Additional Information | https://file.selleck.cn/downloads/struct/iwr-1-endo-iwr-1-chemical-structure-s7086.gif |