Pioglitazone HCl

Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist with EC50 of 0.93 μM and 0.99 μM for human PPARγ and mouse PPARγ, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.

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Trivial name	AD-4833, U-72107E
Catalog Number	S2046
Molecular Formula	C19H20N2O3S.HCl
CAS#	112529-15-4
Inchi	InChI=1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H
Inchi Key	GHUUBYQTCDQWRA-UHFFFAOYSA-N
SMILES	CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3.Cl
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/pioglitazone-hydrochloride-actos.html
Additional Information	https://file.selleck.cn/downloads/struct/pioglitazone-hydrochloride-actos-chemical-structure-s2046.gif