SAR125844
SAR125844 is a potent intravenously active and highly selective Met (c-Met) kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively).
| Trivial name | N/A |
| Catalog Number | S7564 |
| Molecular Formula | C25H23FN8O2S2 |
| CAS# | 1116743-46-4 |
| Inchi | InChI=1S/C25H23FN8O2S2/c26-17-3-1-16(2-4-17)19-7-8-22-30-31-25(34(22)32-19)37-18-5-6-20-21(15-18)38-24(28-20)29-23(35)27-9-10-33-11-13-36-14-12-33/h1-8,15H,9-14H2,(H2,27,28,29,35) |
| Inchi Key | ODIUNTQOXRXOIV-UHFFFAOYSA-N |
| SMILES | C1COCCN1CCNC(=O)NC2=NC3=C(S2)C=C(C=C3)SC4=NN=C5N4N=C(C=C5)C6=CC=C(C=C6)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/sar125844.html |
| Additional Information | https://file.selleck.cn/downloads/struct/sar125844-chemical-structure-s7564.gif |