Entrectinib
Entrectinib is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. Entrectinib (RXDX-101) induces autophagy. Phase 2.
| Trivial name | RXDX-101, NMS-E628 |
| Catalog Number | S7998 |
| Molecular Formula | C31H34F2N6O2 |
| CAS# | 1108743-60-7 |
| Inchi | InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40) |
| Inchi Key | HAYYBYPASCDWEQ-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/entrectinib-rxdx-101.html |
| Additional Information | https://file.selleck.cn/downloads/struct/entrectinib-rxdx-101-nms-e628-chemical-structure-s7998.gif |