Aprocitentan
Aprocitentan (ACT-132577) is a pharmacologically active metabolite of Macitentan. Aprocitentan is an orally active dual antagonist of ETA/ETB with IC50 values of 3.4 nM and 987 nM, and pA2 values of 6.7 and 5.5, respectively.
| Trivial name | ACT-132577 |
| Catalog Number | E4771 |
| Molecular Formula | C14H20N2O3 |
| CAS# | 1103522-45-7 |
| Inchi | InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) |
| Inchi Key | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/aprocitentan.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4771-Aprocitentan-chemical-structure.png |