ITD-1
ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I (TGFBR1) or type II (TGFBR2) TGFβ receptors but potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A.
| Trivial name | N/A |
| Catalog Number | S6713 |
| Molecular Formula | C27H29NO3 |
| CAS# | 1099644-42-4 |
| Inchi | InChI=1S/C27H29NO3/c1-5-31-26(30)23-17(2)28-21-15-27(3,4)16-22(29)25(21)24(23)20-13-11-19(12-14-20)18-9-7-6-8-10-18/h6-14,24,28H,5,15-16H2,1-4H3 |
| Inchi Key | ULFUJLFTRWWLPO-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(NC2=C(C1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C2)(C)C)C |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/itd-1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/itd-1-chemical-structure-s6713.gif |