U0126
Potent and selective non-competitive inhibitor of MAP kinase kinase(MEK). Inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 µM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4.
Catalog Number | ABS-071 |
Alternative Name(s) | 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene |
CAS# | 109511-58-2 |
Inchi | InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+ |
Inchi Key | DVEXZJFMOKTQEZ-JYFOCSDGSA-N |
SMILES | C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N |
Size | Inquiry |
Supplier Page | https://www.agingclocks.com/u0126-item-1535.html |