BS-181
BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy.
| Catalog Number | E7095 |
| Molecular Formula | C19H27N3O5S2 |
| CAS# | 1092443-52-1 |
| Inchi | InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 |
| Inchi Key | IXTMWRCNAAVVAI-UHFFFAOYSA-N |
| SMILES | CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/bs-181.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7095-bs-181-chemical-structure-tube.png |