Poziotinib | MedChemExpress (MCE)

Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFR^wt, HER-2 and HER-4 with IC₅₀s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFR^T790M and EGFR^L858R/T790M, with IC₅₀s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity^[1]^[2].

Price Not Available 10 mM * 1 mL Poziotinib | MedChemExpress (MCE) Supplier Page

Trivial name	Poziotinib
Catalog Number	HY-15730
Alternative Name(s)	HM781-36B; NOV120101
Research Area	Cancer
CAS#	1092364-38-9
Purity	100.0%
SMILES	C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
Size	10 mM * 1 mL
Supplier Page	https://www.medchemexpress.com/Poziotinib.html