PP242
A potent and selective in vitro mTOR inhibitor that targets the ATP domain of mTOR (IC50 = 8 nM). Inhibits other PI 3-Kinases only at much higher concentrations. Recently it has been shown that PP242 is a more effective mTORC1 inhibitor than Rapamycin.
| Catalog Number | ABM-015 |
| Alternative Name(s) | 2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol |
| CAS# | 1092351-67-1 |
| Inchi | InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)/b14-12+ |
| Inchi Key | MTICIDWIKCANDD-WYMLVPIESA-N |
| SMILES | CC(C)N1C2=C(C(=C3C=C4C=C(C=CC4=N3)O)N1)C(=NC=N2)N |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/pp242-item-1460.html |