Ixazomib (MLN2238)

Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.

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Trivial name	N/A
Catalog Number	S2180
Molecular Formula	C13H15NO2S
CAS#	1072833-77-2
Inchi	InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
Inchi Key	BGVLELSCIHASRV-QPEQYQDCSA-N
SMILES	CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C
Size	5mg
Supplier Page	http://www.selleckchem.com/products/MLN-2238.html
Additional Information	https://file.selleck.cn/downloads/struct/MLN2238-chemical-structure-S2180.gif