Ixazomib (MLN2238)
Ixazomib (MLN2238) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM in cell-free assays, respectively, also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites, with IC50 of 31 and 3500 nM. Ixazomib (MLN2238) induces autophagy. Phase 3.
| Trivial name | N/A |
| Catalog Number | S2180 |
| Molecular Formula | C23H24FN5O2 |
| CAS# | 1072833-77-2 |
| SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/MLN-2238.html |
| Additional Information | https://file.selleck.cn/downloads/struct/MLN2238-chemical-structure-S2180.gif |