Xevinapant
Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
| Catalog Number | T6763 |
| Alternative Name(s) | ARRY-334543 , SM-406 , AT406 , Debio-1143 |
| Research Area | Apoptosis |
| Molecular Formula | C32H43N5O4 |
| CAS# | 1071992-99-8 |
| Purity | 99.77% |
| SMILES | CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CC(C)C |
| Size | 2 mg |
| Supplier Page | https://www.targetmol.com/compound/Xevinapant |
| Additional Information | https://www.targetmol.com/datasheet/T6763 |