Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[2].In Vitro: Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].In Vivo: Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models.
Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].