LDN-193189 2HCl
LDN-193189 (DM3189) 2HCl is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
| Trivial name | DM-3189 2HCl |
| Catalog Number | S7507 |
| Molecular Formula | C25H24Cl2N6 |
| CAS# | 1435934-00-1 |
| Inchi | InChI=1S/C25H22N6.ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;/h1-10,15-17,26H,11-14H2;1H |
| Inchi Key | PCCDKTWDGDFRME-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ldn-193189-2hcl.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LDN193189-2hcl-chemical-structure-s7507.gif |