LDN-193189
LDN-193189 (DM3189) is a selective BMP signaling inhibitor, inhibits the ALK1, ALK2, ALK3 and ALK6 with IC50s of 0.8 nM, 0.8 nM, 5.3 nM and 16.7 nM in the kinase assay, respectively. LDN-193189 inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50s of 5 nM and 30 nM in C2C12 cells, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. For cell testing, the water-soluble S7507 LDN-193189 2HCl is recommended.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
| Trivial name | DM3189 |
| Catalog Number | S2618 |
| Molecular Formula | C18H22N4O2 |
| CAS# | 1062368-24-4 |
| Inchi | InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10?,11?,14-,18- |
| Inchi Key | DREIJXJRTLTGJC-CGINBCCASA-N |
| SMILES | C1C2CC3CC(C2)(CC1C3NC4=C5C=CNC5=NC=C4C(=O)N)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/ldn193189.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LDN193189-chemical-structure-S2618.gif |