WYE-354
WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
| Trivial name | N/A |
| Catalog Number | S1266 |
| Molecular Formula | C27H24N2O5 |
| CAS# | 1062169-56-5 |
| Inchi | InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1 |
| Inchi Key | LNDDRUPAICPXIN-GOSISDBHSA-N |
| SMILES | CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/WYE-354.html |
| Additional Information | https://file.selleck.cn/downloads/struct/WYE-354-chemical-structure-S1266.gif |