WYE-354
WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
| Trivial name | N/A |
| Catalog Number | S1266 |
| Molecular Formula | C24H29N7O5 |
| CAS# | 1062169-56-5 |
| Inchi | InChI=1S/C24H29N7O5/c1-34-23(32)26-17-5-3-16(4-6-17)20-27-21(29-11-13-36-14-12-29)19-15-25-31(22(19)28-20)18-7-9-30(10-8-18)24(33)35-2/h3-6,15,18H,7-14H2,1-2H3,(H,26,32) |
| Inchi Key | IMXHGCRIEAKIBU-UHFFFAOYSA-N |
| SMILES | COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)C(=O)OC)C(=N2)N5CCOCC5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/WYE-354.html |
| Additional Information | https://file.selleck.cn/downloads/struct/WYE-354-chemical-structure-S1266.gif |