WYE-687
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
| Trivial name | N/A |
| Catalog Number | S2668 |
| Molecular Formula | C28H32N8O3 |
| CAS# | 1062161-90-3 |
| Inchi | InChI=1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7,10,17-18,23H,8-9,11-16,19H2,1H3,(H,31,37) |
| Inchi Key | VDOCQQKGPJENHJ-UHFFFAOYSA-N |
| SMILES | COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/wye-687.html |
| Additional Information | https://file.selleck.cn/downloads/struct/WYE-687-chemical-structure-s2668.gif |