Momelotinib (CYT387)
Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.
Trivial name | LM-1149 , CYT11387 |
Catalog Number | S2219 |
Molecular Formula | C23H22N6O2 |
CAS# | 1056634-68-4 |
Inchi | InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28) |
Inchi Key | ZVHNDZWQTBEVRY-UHFFFAOYSA-N |
SMILES | C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N |
Size | 50mg |
Supplier Page | http://www.selleckchem.com/products/Cyt387.html |
Additional Information | https://file.selleck.cn/downloads/struct/CYT-387-chemical-structure-S2219.gif |