Momelotinib (CYT387)
Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.
Trivial name | LM-1149 , CYT11387 |
Catalog Number | S2219 |
Molecular Formula | C17H21N3O |
CAS# | 1056634-68-4 |
Inchi | InChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21) |
Inchi Key | AWOPBSAJHCUSAS-UHFFFAOYSA-N |
SMILES | CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C |
Size | 50mg |
Supplier Page | http://www.selleckchem.com/products/Cyt387.html |
Additional Information | https://file.selleck.cn/downloads/struct/CYT-387-chemical-structure-S2219.gif |