Dacomitinib hydrate

Dacomitinib hydrate(PF-00299804, PF-804) is an orally administered, highly selective irreversible inhibitor targeting pan-ERBB receptors, with an IC50 of 6.0 nM for EGFR, 45.7 nM for ERBB2, and 73.7 nM for ERBB4. It also demonstrates anti-tumor activity.

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Trivial name	PF-00299804, PF-804
Catalog Number	E4904
Molecular Formula	C15H22FN3O6
CAS#	1042385-75-0
Inchi	InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1
Inchi Key	GAGWJHPBXLXJQN-UORFTKCHSA-N
SMILES	CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/dacomitinib-hydrate.html
Additional Information	https://file.selleck.cn/downloads/struct/E4904-Dacomitinib-hydrate-chemical-structure.png