Niraparib hydrochloride
Niraparib hydrochloride (MK-4827 hydrochloride) is a potent poly(ADP-ribose)polymerase (PARP) inhibitor with IC50s of 3.8 and 2.1 nM against both the PARP-1 and PARP-2 enzymes, respectively.It inhibits the repair of radiation-induced DNA double-strand breaks, activates apoptosis, and exhibits anti-tumor activity.
| Trivial name | MK-4827 hydrochloride |
| Catalog Number | E4869 |
| Molecular Formula | C23H24FN9O |
| CAS# | 1038915-64-8 |
| Inchi | InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m 0/s1 |
| Inchi Key | LQVXSNNAFNGRAH-QHCPKHFHSA-N |
| SMILES | CC1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/niraparib-hydrochloride.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4869-Niraparib-hydrochloride-chemical-structure.png |