Bemcentinib (R428)

Bemcentinib (R428, BGB324) is an inhibitor of Axl with IC50 of 14 nM, >100-fold selective for Axl versus Abl. Selectivty for Axl is also greater than Mer and Tyro3 (50-to-100- fold more selective) and InsR, EGFR, HER2, and PDGFRβ (100- fold more selective).

Price Not Available 1mg Bemcentinib (R428) Supplier Page

Trivial name	BGB324
Catalog Number	S2841
Molecular Formula	C30H34N8
CAS#	1037624-75-1
Inchi	InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,3 2,33,36)/t25-/m0/s1
Inchi Key	KXMZDGSRSGHMMK-VWLOTQADSA-N
SMILES	C1CCN(C1)C2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76
Size	1mg
Supplier Page	http://www.selleckchem.com/products/r428.html
Additional Information	https://file.selleck.cn/downloads/struct/s2841-bemcentinib-r428-chemical-structure.png