Nanvuranlat (JPH203)
Nanvuranlat (JPH203, KYT-0353, JPH-203SBECD), a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
| Trivial name | KYT-0353, JPH-203SBECD |
| Catalog Number | S8667 |
| Molecular Formula | C23H19Cl2N3O4 |
| CAS# | 1037592-40-7 |
| Inchi | InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1 |
| Inchi Key | XNRZJPQTMQZBCE-SFHVURJKSA-N |
| SMILES | C1=CC=C(C=C1)C2=NC3=CC(=CC(=C3O2)COC4=C(C=C(C=C4Cl)CC(C(=O)O)N)Cl)N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/jph203.html |
| Additional Information | https://file.selleck.cn/downloads/struct/jph203-chemical-structure-s8667.gif |