TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2617 |
| Molecular Formula | C29H34Cl2FN3O3 |
| CAS# | 1035555-63-5 |
| Inchi | InChI=1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,16-17,22-23,25,35-36H,8-11,14H2,1-3H3,(H,33, 37)(H,34,38)/t16-,17-,22-,23-,25+,29+/m0/s1 |
| Inchi Key | IDKAKZRYYDCJDU-HBMMIIHUSA-N |
| SMILES | CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/tak-733.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TAK-733-chemical-structure-s2617.gif |