TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2617 |
| Molecular Formula | C17H15F2IN4O4 |
| CAS# | 1035555-63-5 |
| Inchi | InChI=1S/C17H15F2IN4O4/c1-23-15-12(16(27)24(7-21-15)5-9(26)6-25)14(13(19)17(23)28)22-11-3-2-8(20)4-10(11)18/h2-4,7,9,22,25-26H,5-6H2,1H3/t9-/m1/s1 |
| Inchi Key | RCLQNICOARASSR-SECBINFHSA-N |
| SMILES | CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/tak-733.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TAK-733-chemical-structure-s2617.gif |