TAK-733
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.
| Trivial name | N/A |
| Catalog Number | S2617 |
| Molecular Formula | C18H22N4O2 |
| CAS# | 1035555-63-5 |
| Inchi | InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10?,11?,14-,18- |
| Inchi Key | DREIJXJRTLTGJC-CGINBCCASA-N |
| SMILES | C1C2CC3CC(C2)(CC1C3NC4=C5C=CNC5=NC=C4C(=O)N)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/tak-733.html |
| Additional Information | https://file.selleck.cn/downloads/struct/TAK-733-chemical-structure-s2617.gif |